DNA storage
DNA-based data storage stands as a groundbreaking response to the escalating demand for information preservation, offering unparalleled data density and longevity. However, the high costs of current DNA synthesis and sequencing hinder its widespread adoption. Our research focuses on enhancing the feasibility of DNA as a storage medium through innovative approaches. One key solution is the integration of degenerate DNA bases, expanding the encoding alphabet and significantly reducing the quantity of DNA required for storage. Additionally, DNA micro-disks present a revolutionary advancement, enabling Write-Once-Read-Many (WORM) functionality. These disks preserve data integrity during repeated access and allow for efficient random data retrieval by compartmentalizing stored information. Together, these technologies address the primary barriers of cost and practicality, paving the way for DNA storage to become a scalable and sustainable solution for future data needs. These advancements signify a major leap toward the realization of DNA's full potential in the information age.
Choi, Y., Bae, H. J., Lee, A. C., Choi, H., Lee, D., Ryu, T., ... & Kwon, S. (2020). DNA micro‐disks for the management of DNA‐based data storage with index and write‐once–read‐many (WORM) memory features. Advanced Materials, 32(37), 2001249.
Choi, Y., Ryu, T., Lee, A. C., Choi, H., Lee, H., Park, J., ... & Kwon, S. (2019). High information capacity DNA-based data storage with augmented encoding characters using degenerate bases. Scientific reports, 9(1), 6582.